PINWORM—A$$ment and Pharm Treatment..Mnemonic
1. Eggs are deposited on perianal folds.
2. Eggs may be ingested when people touch their mouth after they scratch their perianal area (autoinfection) or after handling contaminated clothes or other objects (eg, bed linens, curtains, carpeting); handling contaminated objects may also cause a few eggs to become airborne and thus ingested.
3. After eggs are ingested, they travel to the small intestine, where they hatch, releasing larvae.
4. The adult worms establish themselves in the cecal lumen.
5. At night, gravid females migrate outside the anus and lay eggs as they crawl on the skin of the perianal area.
THE “SCOTCH TAPE TEST”
*Note pt is BENDing over for “Tape Test”
HAHA, Get it? and for the “azole” ending I (bc I’m weird) think of pasta.. so spaghetti noodles=pinworms)
Mode of Action
Mebendazole inhibits the formation of the worms’ microtubules and causes the worms’ glucose depletion.
Mebendazole tablets are indicated for the treatment of Enterobius vermicularis (pinworm),Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as preexisting diarrhea and gastrointestinal transit time, degree of infection, and helminth strains. Efficacy rates derived from various studies are shown in the table below:
Mebendazole is contraindicated in persons who have shown hypersensitivity to the drug.
There is no evidence that Mebendazole, even at high doses, is effective for hydatid disease. There have been rare reports of neutropenia and agranulocytosis when Mebendazole was taken for prolonged periods and at dosages substantially above those recommended.
Periodic assessment of organ system functions, including hematopoietic and hepatic, is advisable during prolonged therapy.
Information for Patients
Patients should be informed of the potential risk to the fetus in women taking Mebendazole during pregnancy, especially during the first trimester (See Pregnancy).
Patients should also be informed that cleanliness is important to prevent reinfection and transmission of the infection.
Preliminary evidence suggests that cimetidine inhibits Mebendazole metabolism and may result in an increase in plasma concentrations of Mebendazole.